InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hcfc1

Summary

InnateDB Protein

IDBP-154576.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hcfc1

Protein Name

host cell factor C1

Synonyms

AW060991; HCF; HCF1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033761

InnateDB Gene

IDBG-154574 (Hcfc1)

Protein Structure

UniProt Annotation

Function

Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription respectively) together. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. {ECO:0000269PubMed:9334261, ECO:0000269PubMed:9990006}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9990006}. Cytoplasm {ECO:0000269PubMed:9990006}. Note=HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. Non-processed HCFC1 associates with chromatin. Colocalizes with CREB3 and CANX in the ER (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in liver, pituitary gland, skeletal muscle, kidney, eye and brain (at protein level). Also observed at low level in heart, spleen and lung. {ECO:0000269PubMed:9334261, ECO:0000269PubMed:9990006}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043995	histone acetyltransferase activity (H4-K5 specific)
GO:0043996	histone acetyltransferase activity (H4-K8 specific)
GO:0046972	histone acetyltransferase activity (H4-K16 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0010628	positive regulation of gene expression
GO:0019046	release from viral latency
GO:0043254	regulation of protein complex assembly
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043984	histone H4-K16 acetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050821	protein stabilization

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0005634	nucleus
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0043025	neuronal cell body
GO:0048188	Set1C/COMPASS complex
GO:0070461	SAGA-type complex
GO:0070688	MLL5-L complex
GO:0071339	MLL1 complex