InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Decr2

Summary

InnateDB Protein

IDBP-154588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Decr2

Protein Name

2-4-dienoyl-Coenzyme A reductase 2, peroxisomal

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045621

InnateDB Gene

IDBG-154586 (Decr2)

Protein Structure

UniProt Annotation

Function

Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19- docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Subcellular Localization

Peroxisome {ECO:0000269PubMed:10464321}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity
GO:0016491	oxidoreductase activity
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity

Biological Process

GO:0006636	unsaturated fatty acid biosynthetic process
GO:0008152	metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005777	peroxisome
GO:0005778	peroxisomal membrane

Protein Structure and Domains

PDB ID

MGI:1347059

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR

PFAM

PF00106
PF08659

PRINTS

PR00080
PR00081
PR01397

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt