InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irak1

Summary

InnateDB Protein

IDBP-154753.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Irak1

Protein Name

interleukin-1 receptor-associated kinase 1

Synonyms

AA408924; Il1rak; IRAK; IRAK-1; IRAK1-S; mPLK; Plpk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033769

InnateDB Gene

IDBG-154747 (Irak1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 112 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	49 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	112 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005149	interleukin-1 receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031072	heat shock protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001959	regulation of cytokine-mediated signaling pathway
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0007254	JNK cascade
GO:0007568	aging
GO:0019221	cytokine-mediated signaling pathway
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032494	response to peptidoglycan
GO:0032496	response to lipopolysaccharide
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034605	cellular response to heat
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051259	protein oligomerization
GO:0070498	interleukin-1-mediated signaling pathway
GO:0070555	response to interleukin-1
GO:0071222	cellular response to lipopolysaccharide
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:107420

InterPro

IPR000488 Death domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011029 Death-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00531
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00005
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt