InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rax

Summary

InnateDB Protein

IDBP-154855.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rax

Protein Name

retina and anterior neural fold homeobox

Synonyms

7530406A22Rik; E130303K03Rik; ey-1; ey1; Rx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025396

InnateDB Gene

IDBG-154853 (Rax)

Protein Structure

UniProt Annotation

Function

Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in the photoreceptor and inner nuclear layers.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007389	pattern specification process
GO:0007420	brain development
GO:0021854	hypothalamus development
GO:0043010	camera-type eye development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060173	limb development