Version 5.4
Mus musculus Protein: Cplx4
Summary
InnateDB Protein IDBP-154867.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cplx4
Protein Name complexin 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000025397
InnateDB Gene IDBG-154865 (Cplx4)
Protein Structure
UniProt Annotation
Function Positively regulates a late step in synaptic vesicle exocytosis. {ECO:0000269PubMed:15911881}.
Subcellular Localization Membrane {ECO:0000269PubMed:15911881}; Lipid-anchor {ECO:0000269PubMed:15911881}. Cell junction, synapse {ECO:0000269PubMed:15911881}. Cell membrane {ECO:0000269PubMed:15911881}; Lipid-anchor {ECO:0000269PubMed:15911881}. Note=Enriched at the synaptic terminal.
Disease Associations
Tissue Specificity Present specifically in the retina, at rod photoreceptor ribbon synapses. Not expressed at conventional amacrine cell synapses, nor at cone photoreceptor ribbon synapses (at protein level). {ECO:0000269PubMed:15911881}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0019905 syntaxin binding
Biological Process
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0046928 regulation of neurotransmitter secretion
Cellular Component
GO:0005886 plasma membrane
GO:0030054 cell junction
GO:0045202 synapse
Protein Structure and Domains
PDB ID MGI:2685803
InterPro IPR008849 Synaphin
PFAM PF05835
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80WM3
PhosphoSite PhosphoSite-Q80WM3
TrEMBL
UniProt Splice Variant
Entrez Gene 225644
UniGene Mm.408337
RefSeq NP_663468
MGI ID
MGI Symbol Cplx4
OMIM
CCDS CCDS29312
HPRD
IMGT
EMBL AK044262 AY264291 BC016082 BC029011
GenPept AAH16082 AAH29011 AAP22134 BAC31843

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca