InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dock8

Summary

InnateDB Protein

IDBP-154890.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dock8

Protein Name

dedicator of cytokinesis 8

Synonyms

1200017A24Rik; 5830472H07Rik; A130095G14Rik; AI461977;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025831

InnateDB Gene

IDBG-154888 (Dock8)

Protein Structure

UniProt Annotation

Function

Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0001771	immunological synapse formation
GO:0007264	small GTPase mediated signal transduction
GO:0036336	dendritic cell migration
GO:0043087	regulation of GTPase activity
GO:0061485	memory T cell proliferation
GO:0070233	negative regulation of T cell apoptotic process