Version 5.4
| Mus musculus Protein: Zfyve28 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-154964.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Zfyve28 | ||||||||
| Protein Name | zinc finger, FYVE domain containing 28 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000092464 | ||||||||
| InnateDB Gene | IDBG-154960 (Zfyve28) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm, cytosol. Early endosome membrane. Note=Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated (By similarity). {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Enriched in brain (at protein level). {ECO:0000269PubMed:19460345}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2684992 | ||||||||
| InterPro |
IPR000306
FYVE zinc finger IPR011011 Zinc finger, FYVE/PHD-type IPR012340 Nucleic acid-binding, OB-fold IPR017455 Zinc finger, FYVE-related |
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| PFAM |
PF01363
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00064
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q6ZPK7 | ||||||||
| PhosphoSite | PhosphoSite-Q6ZPK7 | ||||||||
| TrEMBL | Q8CG84 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 231125 | ||||||||
| UniGene | Mm.113388 | ||||||||
| RefSeq | NP_001015039 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Zfyve28 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS39068 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK129414 BC042774 BC139050 BC139051 | ||||||||
| GenPept | AAH42774 AAI39051 AAI39052 BAC98224 | ||||||||