InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif2ak3

Summary

InnateDB Protein

IDBP-155038.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2ak3

Protein Name

eukaryotic translation initiation factor 2 alpha kinase 3

Synonyms

AI427929; Pek; Perk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034093

InnateDB Gene

IDBG-155036 (Eif2ak3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0042802	identical protein binding

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0002063	chondrocyte development
GO:0006412	translation
GO:0006468	protein phosphorylation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006983	ER overload response
GO:0007029	endoplasmic reticulum organization
GO:0007595	lactation
GO:0009967	positive regulation of signal transduction
GO:0010629	negative regulation of gene expression
GO:0017148	negative regulation of translation
GO:0019217	regulation of fatty acid metabolic process
GO:0019722	calcium-mediated signaling
GO:0030282	bone mineralization
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031016	pancreas development
GO:0031018	endocrine pancreas development
GO:0031642	negative regulation of myelination
GO:0032055	negative regulation of translation in response to stress
GO:0032092	positive regulation of protein binding
GO:0032933	SREBP signaling pathway
GO:0034976	response to endoplasmic reticulum stress
GO:0043066	negative regulation of apoptotic process
GO:0045444	fat cell differentiation
GO:0046777	protein autophosphorylation
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0051260	protein homooligomerization
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular Component

GO:0005623	cell
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1341830

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt