Version 5.4
Mus musculus Protein: Lmln
Summary
InnateDB Protein IDBP-155090.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lmln
Protein Name leishmanolysin-like (metallopeptidase M8 family)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000023497
InnateDB Gene IDBG-155088 (Lmln)
Protein Structure
UniProt Annotation
Function Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration. {ECO:0000250}.
Subcellular Localization Cytoplasm. Lipid droplet {ECO:0000250}. Note=Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004222 metalloendopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007067 mitotic nuclear division
GO:0007155 cell adhesion
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0005811 lipid particle
GO:0005925 focal adhesion
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:2444736
InterPro IPR001577 Peptidase M8, leishmanolysin
PFAM PF01457
PRINTS PR00782
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BMN4
PhosphoSite PhosphoSite-Q8BMN4
TrEMBL
UniProt Splice Variant
Entrez Gene 239833
UniGene Mm.440458
RefSeq NP_766411
MGI ID
MGI Symbol Lmln
OMIM
CCDS CCDS28127
HPRD
IMGT
EMBL AK030463 BC111899 BC112428
GenPept AAI11900 AAI12429 BAC26972

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca