InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bop1

Summary

InnateDB Protein

IDBP-155119.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bop1

Protein Name

block of proliferation 1

Synonyms

AU020183; AW146150; D18861; Erb1p; Kiaa0124; mKIAA0124;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023217

InnateDB Gene

IDBG-155117 (Bop1)

Protein Structure

UniProt Annotation

Function

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255HAMAP-Rule:MF_03027, ECO:0000269PubMed:10891491, ECO:0000269PubMed:11390653, ECO:0000269PubMed:12048210}.

Subcellular Localization

Nucleus, nucleolus. Nucleus, nucleoplasm.

Disease Associations

Tissue Specificity

Expressed in brain, gut, heart, kidney, liver, lung, muscle, ovary, skin, spleen and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043021	ribonucleoprotein complex binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000448	cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364	rRNA processing
GO:0008283	cell proliferation
GO:0042273	ribosomal large subunit biogenesis
GO:0051726	regulation of cell cycle