InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Flna

Summary

InnateDB Protein

IDBP-155136.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Flna

Protein Name

filamin, alpha

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033699

InnateDB Gene

IDBG-155134 (Flna)

Protein Structure

UniProt Annotation

Function

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins (By similarity). Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. {ECO:0000250, ECO:0000269PubMed:22121117, ECO:0000269PubMed:9412467}.

Subcellular Localization

Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in Purkinje cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 119 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	119 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0003779	actin binding
GO:0004871	signal transducer activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017048	Rho GTPase binding
GO:0017160	Ral GTPase binding
GO:0031267	small GTPase binding
GO:0031852	mu-type opioid receptor binding
GO:0034988	Fc-gamma receptor I complex binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0046332	SMAD binding
GO:0048365	Rac GTPase binding
GO:0051015	actin filament binding

Biological Process

GO:0001837	epithelial to mesenchymal transition
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0030030	cell projection organization
GO:0030036	actin cytoskeleton organization
GO:0031532	actin cytoskeleton reorganization
GO:0034394	protein localization to cell surface
GO:0042177	negative regulation of protein catabolic process
GO:0042384	cilium assembly
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0043113	receptor clustering
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045022	early endosome to late endosome transport
GO:0045184	establishment of protein localization
GO:0050821	protein stabilization
GO:0051220	cytoplasmic sequestering of protein
GO:0051764	actin crosslink formation
GO:0090307	spindle assembly involved in mitosis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030863	cortical cytoskeleton
GO:0031523	Myb complex
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0097440	apical dendrite