InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Flna

Summary

InnateDB Protein

IDBP-155138.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Flna

Protein Name

filamin, alpha

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098997

InnateDB Gene

IDBG-155134 (Flna)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 119 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	119 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0003779	actin binding
GO:0004871	signal transducer activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017160	Ral GTPase binding
GO:0031852	mu-type opioid receptor binding
GO:0034988	Fc-gamma receptor I complex binding
GO:0042803	protein homodimerization activity
GO:0046332	SMAD binding
GO:0048365	Rac GTPase binding
GO:0051015	actin filament binding

Biological Process

GO:0001837	epithelial to mesenchymal transition
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0030036	actin cytoskeleton organization
GO:0031532	actin cytoskeleton reorganization
GO:0034394	protein localization to cell surface
GO:0042177	negative regulation of protein catabolic process
GO:0042384	cilium assembly
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0043113	receptor clustering
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045022	early endosome to late endosome transport
GO:0045184	establishment of protein localization
GO:0050821	protein stabilization
GO:0051220	cytoplasmic sequestering of protein
GO:0051764	actin crosslink formation
GO:0090307	spindle assembly involved in mitosis

Cellular Component

GO:0005634	nucleus
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0030863	cortical cytoskeleton
GO:0031523	Myb complex
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0097440	apical dendrite