Version 5.4
Mus musculus Protein: Neurl1b
Summary
InnateDB Protein IDBP-155179.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Neurl1b
Protein Name neuralized homolog 1b (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000051481
InnateDB Gene IDBG-155177 (Neurl1b)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands. {ECO:0000269PubMed:17003037, ECO:0000269PubMed:19723503}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19723503}.
Disease Associations
Tissue Specificity Expressed in the limb buds and dorsal root ganglia. Expressed in brain and kidney and at low levels in the heart. {ECO:0000269PubMed:17003037}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0007219 Notch signaling pathway
GO:0008150 biological_process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:3643092
InterPro IPR001841 Zinc finger, RING-type
IPR006573 NEUZ
PFAM PF13639
PF14634
PF07177
PRINTS
PIRSF
SMART SM00184
SM00588
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0MW30
PhosphoSite PhosphoSite-Q0MW30
TrEMBL
UniProt Splice Variant
Entrez Gene 240055
UniGene Mm.311295
RefSeq NP_001075125
MGI ID
MGI Symbol Neurl1b
OMIM
CCDS CCDS37513
HPRD
IMGT
EMBL DQ839448 GQ414760
GenPept ABH10575 ACV53566

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca