InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vegfc

Summary

InnateDB Protein

IDBP-155242.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vegfc

Protein Name

vascular endothelial growth factor C

Synonyms

AW228853; VEGF-C;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033919

InnateDB Gene

IDBG-155240 (Vegfc)

Protein Structure

UniProt Annotation

Function

Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. {ECO:0000269PubMed:9012504, ECO:0000269PubMed:9247316}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in adult heart, brain, spleen, lung, liver, skeletal muscle, kidney, testis and intestine with higher levels in heart, brain and kidney. Isoform 4 levels are very low. Isoform 3 is mostly expressed in liver and has reduced expression level in other tissues. Isoform 2 is mostly expressed in brain and kidney, although a lower level expression in other tissues is also detectable. {ECO:0000269PubMed:20415667, ECO:0000269PubMed:9012504, ECO:0000269PubMed:9247316}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042056	chemoattractant activity
GO:0043185	vascular endothelial growth factor receptor 3 binding

Biological Process

GO:0001525	angiogenesis
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002052	positive regulation of neuroblast proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0016331	morphogenesis of embryonic epithelium
GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031954	positive regulation of protein autophosphorylation
GO:0042493	response to drug
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045776	negative regulation of blood pressure
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050714	positive regulation of protein secretion
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051781	positive regulation of cell division
GO:0060754	positive regulation of mast cell chemotaxis
GO:1901492	positive regulation of lymphangiogenesis