Homo sapiens Protein: SPATA13 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-15525.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | SPATA13 | ||||||||||||||||||
Protein Name | spermatogenesis associated 13 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000371527 | ||||||||||||||||||
InnateDB Gene | IDBG-15519 (SPATA13) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up- regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269PubMed:17145773, ECO:0000269PubMed:17599059, ECO:0000269PubMed:19151759, ECO:0000269PubMed:19893577, ECO:0000269PubMed:19934221}. | ||||||||||||||||||
Subcellular Localization | Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors. {ECO:0000269PubMed:17145773, ECO:0000269PubMed:17599059, ECO:0000269PubMed:19893577}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000219
Dbl homology (DH) domain IPR001452 SH3 domain IPR001849 Pleckstrin homology domain IPR011511 Variant SH3 domain |
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PFAM |
PF00621
PF00018 PF14604 PF00169 PF07653 |
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PRINTS |
PR00452
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PIRSF | |||||||||||||||||||
SMART |
SM00325
SM00326 SM00233 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q96N96 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q96N96 | ||||||||||||||||||
TrEMBL | A0A024RDM6 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 221178 | ||||||||||||||||||
UniGene | Hs.735225 | ||||||||||||||||||
RefSeq | NP_694568 | ||||||||||||||||||
HUGO | HGNC:23222 | ||||||||||||||||||
OMIM | 613324 | ||||||||||||||||||
CCDS | CCDS9305 | ||||||||||||||||||
HPRD | 15427 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AK055770 AK074117 AK097217 AK123031 AK160371 AK298717 AK299981 AK301149 AL136963 AL139324 AL359736 AL445985 BC109290 BC109291 BK006072 CH471075 | ||||||||||||||||||
GenPept | AAI09291 AAI09292 BAB71009 BAB84943 BAC04977 BAD18714 BAG53856 BAG60873 BAG61802 BAG62740 CAH72289 CAH72290 DAA05848 EAX08331 EAX08332 | ||||||||||||||||||