Version 5.4
Mus musculus Protein: Snx4
Summary
InnateDB Protein IDBP-155278.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Snx4
Protein Name sorting nexin 4
Synonyms 1810036H14Rik; AI037066;
Species Mus musculus
Ensembl Protein ENSMUSP00000023502
InnateDB Gene IDBG-155276 (Snx4)
Protein Structure
UniProt Annotation
Function May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (By similarity). {ECO:0000250}.
Subcellular Localization Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0032456 endocytic recycling
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005868 cytoplasmic dynein complex
GO:0031901 early endosome membrane
Protein Structure and Domains
PDB ID MGI:1916400
InterPro IPR001683 Phox homologous domain
IPR015404 Vps5 C-terminal
PFAM PF00787
PF09325
PRINTS
PIRSF
SMART SM00312
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91YJ2
PhosphoSite PhosphoSite-Q91YJ2
TrEMBL Q80X54
UniProt Splice Variant
Entrez Gene 69150
UniGene Mm.407232
RefSeq NP_542124
MGI ID
MGI Symbol Snx4
OMIM
CCDS CCDS28129
HPRD
IMGT
EMBL AK135356 BC016599 BC050851
GenPept AAH16599 AAH50851 BAE22501

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca