Version 5.4
Mus musculus Protein: Mxd3
Summary
InnateDB Protein IDBP-155318.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mxd3
Protein Name Max dimerization protein 3
Synonyms 4631412E13Rik; bHLHc13; Mad3;
Species Mus musculus
Ensembl Protein ENSMUSP00000021941
InnateDB Gene IDBG-155316 (Mxd3)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. {ECO:0000269PubMed:8521822}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00981, ECO:0000269PubMed:8521822}.
Disease Associations
Tissue Specificity Expressed only in the proliferating areas of the testis and thymus. {ECO:0000269PubMed:11154258}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:104987
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80US8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 17121
UniGene
RefSeq NP_057871
MGI ID
MGI Symbol Mxd3
OMIM
CCDS CCDS26543
HPRD
IMGT
EMBL AK138742 BC051970 U32394
GenPept AAB02794 AAH51970 BAE23764

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca