InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfp148

Summary

InnateDB Protein

IDBP-155356.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp148

Protein Name

zinc finger protein 148

Synonyms

2210405J08Rik; AI480666; AW045217; BERF-1; BFCOL1; ZBP-89; Znf148;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087106

InnateDB Gene

IDBG-155354 (Zfp148)

Protein Structure

UniProt Annotation

Function

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000269PubMed:9417107}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Strong expression detected in brain, lung, liver and kidney, with lower levels detected in spleen, skeletal muscle, testis and heart. {ECO:0000269PubMed:9417107}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0007276	gamete generation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter