InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lman2

Summary

InnateDB Protein

IDBP-155371.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lman2

Protein Name

lectin, mannose-binding 2

Synonyms

1110003H06Rik; 1300009F09Rik; AA408240; AL023023; AU040819; GP36B; VIP36;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021940

InnateDB Gene

IDBG-155369 (Lman2)

Protein Structure

UniProt Annotation

Function

Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0003674	molecular_function
GO:0005537	mannose binding
GO:0030246	carbohydrate binding
GO:0031072	heat shock protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0008150	biological_process
GO:0015031	protein transport
GO:0050766	positive regulation of phagocytosis

Cellular Component

GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome