InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: A930001N09Rik

Summary

InnateDB Protein

IDBP-155385.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

A930001N09Rik

Protein Name

RIKEN cDNA A930001N09 gene

Synonyms

A930001N09Rik; LRF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059102

InnateDB Gene

IDBG-155383 (A930001N09Rik)

Protein Structure

UniProt Annotation

Function

Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Colocalizes with CREB3 in nuclear foci. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in intestin, testis, heart and kidney, weakly in brain adipose, colon, liver, lung and skeletal. {ECO:0000269PubMed:18391022}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006810	transport
GO:0006986	response to unfolded protein
GO:0032388	positive regulation of intracellular transport
GO:0034976	response to endoplasmic reticulum stress
GO:0045732	positive regulation of protein catabolic process
GO:0051222	positive regulation of protein transport
GO:1900102	negative regulation of endoplasmic reticulum unfolded protein response