InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dmrt1

Summary

InnateDB Protein

IDBP-155405.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dmrt1

Protein Name

doublesex and mab-3 related transcription factor 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025755

InnateDB Gene

IDBG-155403 (Dmrt1)

Protein Structure

UniProt Annotation

Function

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. {ECO:0000269PubMed:11040213, ECO:0000269PubMed:17540358, ECO:0000269PubMed:20007774, ECO:0000269PubMed:20616082, ECO:0000269PubMed:20951351, ECO:0000269PubMed:21621532, ECO:0000269PubMed:21775990}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00070, ECO:0000269PubMed:11040213}.

Disease Associations

Tissue Specificity

Testis-specific. In adult testis, expressed in Sertoli cells in all regions of the seminiferous tubules. Expressed dynamically in premeiotic germ cells (spermatogonia), with high expression only in regions of the seminiferous tubule that are early in the spermatogenic cycle (at protein level). Expressed in all mitotic spermatogonia. Expression decreases with the onset of spermatogonial differentiation and disappears at the initiation of meiosis. {ECO:0000269PubMed:11040213, ECO:0000269PubMed:20951351}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000902	cell morphogenesis
GO:0002176	male germ cell proliferation
GO:0003006	developmental process involved in reproduction
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0008354	germ cell migration
GO:0008584	male gonad development
GO:0030238	male sex determination
GO:0035556	intracellular signal transduction
GO:0045835	negative regulation of meiosis
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046661	male sex differentiation
GO:0048599	oocyte development
GO:0060008	Sertoli cell differentiation
GO:0060009	Sertoli cell development
GO:0060903	positive regulation of meiosis I
GO:1900107	regulation of nodal signaling pathway
GO:2000020	positive regulation of male gonad development