InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SERPINF2

Summary

InnateDB Protein

IDBP-15546.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINF2

Protein Name

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

Synonyms

A2AP; AAP; ALPHA-2-PI; API; PLI;

Species

Homo sapiens

Ensembl Protein

ENSP00000371493

InnateDB Gene

IDBG-15544 (SERPINF2)

Protein Structure

UniProt Annotation

Function

Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. {ECO:0000269PubMed:15853774}.

Subcellular Localization

Secreted.

Disease Associations

Alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]: An autosomal recessive disorder resulting in severe hemorrhagic diathesis. {ECO:0000269PubMed:10583218, ECO:0000269PubMed:2572590}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed by the liver and secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004866	endopeptidase inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002034	regulation of blood vessel size by renin-angiotensin
GO:0002576	platelet degranulation
GO:0006953	acute-phase response
GO:0007596	blood coagulation
GO:0010757	negative regulation of plasminogen activation
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0030168	platelet activation
GO:0030199	collagen fibril organization
GO:0032967	positive regulation of collagen biosynthetic process
GO:0042730	fibrinolysis
GO:0045597	positive regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0048514	blood vessel morphogenesis
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051496	positive regulation of stress fiber assembly
GO:0051918	negative regulation of fibrinolysis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071636	positive regulation of transforming growth factor beta production
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin

Cellular Component

GO:0005576	extracellular region
GO:0005577	fibrinogen complex
GO:0005615	extracellular space
GO:0009986	cell surface
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle