InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nkx2-5

Summary

InnateDB Protein

IDBP-155466.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nkx2-5

Protein Name

NK2 transcription factor related, locus 5 (Drosophila)

Synonyms

Csx; Nkx-2.5; Nkx2.5; tinman;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015723

InnateDB Gene

IDBG-155464 (Nkx2-5)

Protein Structure

UniProt Annotation

Function

Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B. Together with PBX1, it is required for spleen development through a mechanism that involves CDKN2B repression. {ECO:0000269PubMed:22560297, ECO:0000269PubMed:9584153}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly in the adult and embryonic heart, and to a lesser extent in lingual muscle, spleen and stomach.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0010736	serum response element binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001570	vasculogenesis
GO:0001947	heart looping
GO:0003007	heart morphogenesis
GO:0003148	outflow tract septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003161	cardiac conduction system development
GO:0003162	atrioventricular node development
GO:0003166	bundle of His development
GO:0003168	Purkinje myocyte differentiation
GO:0003208	cardiac ventricle morphogenesis
GO:0003211	cardiac ventricle formation
GO:0003221	right ventricular cardiac muscle tissue morphogenesis
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0003278	apoptotic process involved in heart morphogenesis
GO:0003285	septum secundum development
GO:0003342	proepicardium development
GO:0003350	pulmonary myocardium development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007492	endoderm development
GO:0007507	heart development
GO:0007512	adult heart development
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0010735	positive regulation of transcription via serum response element binding
GO:0010765	positive regulation of sodium ion transport
GO:0010832	negative regulation of myotube differentiation
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030509	BMP signaling pathway
GO:0030878	thyroid gland development
GO:0035050	embryonic heart tube development
GO:0043066	negative regulation of apoptotic process
GO:0043586	tongue development
GO:0045214	sarcomere organization
GO:0045666	positive regulation of neuron differentiation
GO:0045823	positive regulation of heart contraction
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048536	spleen development
GO:0048738	cardiac muscle tissue development
GO:0051891	positive regulation of cardioblast differentiation
GO:0055005	ventricular cardiac myofibril assembly
GO:0055007	cardiac muscle cell differentiation
GO:0055008	cardiac muscle tissue morphogenesis
GO:0055014	atrial cardiac muscle cell development
GO:0055015	ventricular cardiac muscle cell development
GO:0055117	regulation of cardiac muscle contraction
GO:0060037	pharyngeal system development
GO:0060038	cardiac muscle cell proliferation
GO:0060043	regulation of cardiac muscle cell proliferation
GO:0060047	heart contraction
GO:0060048	cardiac muscle contraction
GO:0060070	canonical Wnt signaling pathway
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060347	heart trabecula formation
GO:0060412	ventricular septum morphogenesis
GO:0060413	atrial septum morphogenesis
GO:0060928	atrioventricular node cell development
GO:0060929	atrioventricular node cell fate commitment
GO:0060971	embryonic heart tube left/right pattern formation
GO:0072358	cardiovascular system development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1901387	positive regulation of voltage-gated calcium channel activity