InnateDB Protein
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IDBP-15548.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SERPINF2
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Protein Name
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serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
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Synonyms
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A2AP; AAP; ALPHA-2-PI; API; PLI;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000321853
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InnateDB Gene
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IDBG-15544 (SERPINF2)
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Protein Structure
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Function |
Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. {ECO:0000269PubMed:15853774}.
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Subcellular Localization |
Secreted.
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Disease Associations |
Alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]: An autosomal recessive disorder resulting in severe hemorrhagic diathesis. {ECO:0000269PubMed:10583218, ECO:0000269PubMed:2572590}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed by the liver and secreted in plasma.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
|
Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0002034
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regulation of blood vessel size by renin-angiotensin
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GO:0002576
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platelet degranulation
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GO:0006953
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acute-phase response
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GO:0007596
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blood coagulation
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GO:0010033
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response to organic substance
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GO:0010757
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negative regulation of plasminogen activation
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GO:0010951
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negative regulation of endopeptidase activity
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GO:0030162
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regulation of proteolysis
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GO:0030168
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platelet activation
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GO:0030199
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collagen fibril organization
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GO:0032967
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positive regulation of collagen biosynthetic process
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GO:0042730
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fibrinolysis
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GO:0045597
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positive regulation of cell differentiation
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0046330
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positive regulation of JNK cascade
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GO:0048514
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blood vessel morphogenesis
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GO:0048661
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positive regulation of smooth muscle cell proliferation
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GO:0051496
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positive regulation of stress fiber assembly
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GO:0051918
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negative regulation of fibrinolysis
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GO:0070374
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positive regulation of ERK1 and ERK2 cascade
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GO:0071636
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positive regulation of transforming growth factor beta production
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GO:2000049
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positive regulation of cell-cell adhesion mediated by cadherin
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Cellular Component |
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PDB ID |
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InterPro |
IPR023796
Serpin domain
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PFAM |
PF00079
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PRINTS |
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PIRSF |
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SMART |
SM00093
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TIGRFAMs |
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Modification |
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SwissProt |
P08697
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PhosphoSite |
PhosphoSite-P08697
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TrEMBL |
C9JMH6
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UniProt Splice Variant |
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Entrez Gene |
5345
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UniGene |
Hs.159509
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RefSeq |
NP_000925
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HUGO |
HGNC:9075
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OMIM |
613168
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CCDS |
CCDS11011
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HPRD |
02029
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IMGT |
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EMBL |
AC130343
AK303763
BC031592
D00116
D00174
J02654
M20782
M20783
M20784
M20785
M20786
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GenPept |
AAA35543
AAA51554
AAH31592
BAA00070
BAA00124
BAG64729
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