InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dmrt3

Summary

InnateDB Protein

IDBP-155505.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dmrt3

Protein Name

doublesex and mab-3 related transcription factor 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046812

InnateDB Gene

IDBG-155503 (Dmrt3)

Protein Structure

UniProt Annotation

Function

Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development. {ECO:0000269PubMed:22932389}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00070}.

Disease Associations

Tissue Specificity

Expressed in the ventral spinal cord, in a restrical population of neurons migrating ventrically in the developing spinal cord at E11.5. {ECO:0000269PubMed:22932389}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007628	adult walking behavior
GO:0019226	transmission of nerve impulse
GO:0021521	ventral spinal cord interneuron specification
GO:0042487	regulation of odontogenesis of dentin-containing tooth
GO:0046661	male sex differentiation