InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plcl1

Summary

InnateDB Protein

IDBP-155515.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plcl1

Protein Name

phospholipase C-like 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037854

InnateDB Gene

IDBG-155511 (Plcl1)

Protein Structure

UniProt Annotation

Function

Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Acts as a inhibitor of PPP1C (By similarity). Involved in the assembly and/or the trafficking of gamma-2 subunit-containing GABA A receptors. {ECO:0000250, ECO:0000269PubMed:16854455, ECO:0000269PubMed:17301177}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0050811	GABA receptor binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0033135	regulation of peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:1900122	positive regulation of receptor binding

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:3036262

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00168
PF00388
PF00387
PF00169
PF09279

PRINTS

PR00360
PR00390

PIRSF

SMART

SM00239
SM00148
SM00149
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt