InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psen1

Summary

InnateDB Protein

IDBP-155524.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psen1

Protein Name

presenilin 1

Synonyms

Ad3h; PS-1; PS1; S182;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048363

InnateDB Gene

IDBG-155522 (Psen1)

Protein Structure

UniProt Annotation

Function

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 103 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	103 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004190	aspartic-type endopeptidase activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0030165	PDZ domain binding
GO:0045296	cadherin binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000186	activation of MAPKK activity
GO:0001568	blood vessel development
GO:0001708	cell fate specification
GO:0001756	somitogenesis
GO:0001764	neuron migration
GO:0001921	positive regulation of receptor recycling
GO:0001933	negative regulation of protein phosphorylation
GO:0001934	positive regulation of protein phosphorylation
GO:0001947	heart looping
GO:0002244	hematopoietic progenitor cell differentiation
GO:0002286	T cell activation involved in immune response
GO:0002573	myeloid leukocyte differentiation
GO:0006469	negative regulation of protein kinase activity
GO:0006486	protein glycosylation
GO:0006509	membrane protein ectodomain proteolysis
GO:0006816	calcium ion transport
GO:0006839	mitochondrial transport
GO:0006874	cellular calcium ion homeostasis
GO:0006914	autophagy
GO:0006974	cellular response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0007176	regulation of epidermal growth factor-activated receptor activity
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007420	brain development
GO:0007507	heart development
GO:0007611	learning or memory
GO:0007613	memory
GO:0009791	post-embryonic development
GO:0015031	protein transport
GO:0015813	L-glutamate transport
GO:0015871	choline transport
GO:0016080	synaptic vesicle targeting
GO:0016337	single organismal cell-cell adhesion
GO:0016485	protein processing
GO:0021795	cerebral cortex cell migration
GO:0021870	Cajal-Retzius cell differentiation
GO:0021904	dorsal/ventral neural tube patterning
GO:0021987	cerebral cortex development
GO:0022008	neurogenesis
GO:0030182	neuron differentiation
GO:0030326	embryonic limb morphogenesis
GO:0030900	forebrain development
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0034205	beta-amyloid formation
GO:0035282	segmentation
GO:0035556	intracellular signal transduction
GO:0040011	locomotion
GO:0042640	anagen
GO:0042987	amyloid precursor protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043393	regulation of protein binding
GO:0043406	positive regulation of MAP kinase activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0043589	skin morphogenesis
GO:0044267	cellular protein metabolic process
GO:0045860	positive regulation of protein kinase activity
GO:0048167	regulation of synaptic plasticity
GO:0048538	thymus development
GO:0048666	neuron development
GO:0048705	skeletal system morphogenesis
GO:0048854	brain morphogenesis
GO:0050435	beta-amyloid metabolic process
GO:0050673	epithelial cell proliferation
GO:0050771	negative regulation of axonogenesis
GO:0050820	positive regulation of coagulation
GO:0050852	T cell receptor signaling pathway
GO:0051402	neuron apoptotic process
GO:0051444	negative regulation of ubiquitin-protein transferase activity
GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis
GO:0051604	protein maturation
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060075	regulation of resting membrane potential
GO:0070588	calcium ion transmembrane transport
GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0000776	kinetochore
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005640	nuclear outer membrane
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005765	lysosomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005790	smooth endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005938	cell cortex
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030018	Z disc
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0031410	cytoplasmic vesicle
GO:0031594	neuromuscular junction
GO:0035253	ciliary rootlet
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0043227	membrane-bounded organelle
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070765	gamma-secretase complex