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InnateDB Protein
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IDBP-155687.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tyw5
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Protein Name
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RIKEN cDNA 1110034B05 gene
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Synonyms
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1110034B05Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000078912
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InnateDB Gene
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IDBG-155683 (Tyw5)
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Protein Structure
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| Function |
tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes (By similarity). {ECO:0000250}.
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| Subcellular Localization |
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
| Accession |
GO Term |
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GO:0000049
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tRNA binding
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GO:0005506
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iron ion binding
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GO:0016706
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oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
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GO:0042803
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protein homodimerization activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:1915986
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
A2RSX7
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
68736
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| UniGene |
Mm.288490
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Tyw5
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| OMIM |
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| CCDS |
CCDS48265
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| HPRD |
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| IMGT |
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| EMBL |
AK139666
BC099495
BC132289
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| GenPept |
AAI32290
BAE24098
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Version 5.4