InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Papolg

Summary

InnateDB Protein

IDBP-155692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Papolg

Protein Name

poly(A) polymerase gamma

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020513

InnateDB Gene

IDBG-155688 (Papolg)

Protein Structure

UniProt Annotation

Function

Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004652	polynucleotide adenylyltransferase activity
GO:0005524	ATP binding
GO:0016779	nucleotidyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006378	mRNA polyadenylation
GO:0031123	RNA 3'-end processing
GO:0043631	RNA polyadenylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2442119

InterPro

IPR002934 Nucleotidyl transferase domain
IPR007010 Poly(A) polymerase, RNA-binding domain
IPR007012 Poly(A) polymerase, central domain
IPR011068 Nucleotidyltransferase, class I, C-terminal-like
IPR014492 Poly(A) polymerase

PFAM

PF01909
PF04926
PF04928

PRINTS

PIRSF

PIRSF018425

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6PCL9