InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpm6a

Summary

InnateDB Protein

IDBP-155756.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpm6a

Protein Name

glycoprotein m6a

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033915

InnateDB Gene

IDBG-155754 (Gpm6a)

Protein Structure

UniProt Annotation

Function

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. Conflictingly, PubMed:22162747 reports that induced cellular protrusions are simple membrane-wrapped tubules without actin or tubulin-based cytoskeletons and with Gpm6a gliding along membrane edges indicative for a function in actin-independent membrane deformation. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO:0000269PubMed:18522499, ECO:0000269PubMed:18776950, ECO:0000269PubMed:22162747}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:21714103}; Multi-pass membrane protein {ECO:0000269PubMed:21714103}. Cell projection, axon {ECO:0000269PubMed:21714103}. Cell projection, dendritic spine {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (By similarity). Localized to the growth cone edge membrane of elongating axons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed in the CNS. Found especially in the granule cell layer of the cerebellum but not in the molecular layer or white matter. Expressed in the immature embryonic retina including the nerve fiber layer (NFL), inner plexiform layer (IPL), and outer plexiform layer (OPL). Weakly expressed in processes of Mueller glia cells. {ECO:0000269PubMed:18776950}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005262	calcium channel activity
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0003407	neural retina development
GO:0007416	synapse assembly
GO:0048812	neuron projection morphogenesis
GO:0048863	stem cell differentiation
GO:0051491	positive regulation of filopodium assembly
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030175	filopodium
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0044295	axonal growth cone
GO:0070062	extracellular vesicular exosome