InnateDB Protein
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IDBP-155776.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ccbl1
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Protein Name
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cysteine conjugate-beta lyase 1
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Synonyms
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2010009K05Rik; AI182306; Gtk; Kat1; KatI;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000038612
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InnateDB Gene
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IDBG-155774 (Ccbl1)
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Protein Structure
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Function |
Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0016212
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kynurenine-oxoglutarate transaminase activity
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GO:0030170
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pyridoxal phosphate binding
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GO:0042803
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protein homodimerization activity
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GO:0047312
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L-phenylalanine:pyruvate aminotransferase activity
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GO:0047316
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glutamine-phenylpyruvate transaminase activity
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GO:0047804
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cysteine-S-conjugate beta-lyase activity
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GO:0047945
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L-glutamine:pyruvate aminotransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1917516
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InterPro |
IPR004839
Aminotransferase, class I/classII
IPR015424
Pyridoxal phosphate-dependent transferase
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PFAM |
PF00155
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BTY1
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PhosphoSite |
PhosphoSite-Q8BTY1
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TrEMBL |
Q05CI8
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UniProt Splice Variant |
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Entrez Gene |
70266
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UniGene |
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RefSeq |
XP_006498377
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MGI ID |
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MGI Symbol |
Ccbl1
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OMIM |
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CCDS |
CCDS15874
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HPRD |
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IMGT |
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EMBL |
AK042391
AK088404
BC016206
BC025124
BC052047
CH466542
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GenPept |
AAH16206
AAH25124
AAH52047
BAC31248
BAC40333
EDL08449
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