InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psmg2

Summary

InnateDB Protein

IDBP-155847.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psmg2

Protein Name

proteasome (prosome, macropain) assembly chaperone 2

Synonyms

1700017I17Rik; AW545363; Clast3; Tnfsf5ip1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025418

InnateDB Gene

IDBG-155845 (Psmg2)

Protein Structure

UniProt Annotation

Function

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity). {ECO:0000250UniProtKB:Q969U7}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12147697}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0007094	mitotic spindle assembly checkpoint
GO:0043066	negative regulation of apoptotic process
GO:0043248	proteasome assembly
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1922901

InterPro

IPR016562 Proteasome assembly chaperone 2, eukaryotic
IPR019151 Proteasome assembly chaperone 2

PFAM

PF09754

PRINTS

PIRSF

PIRSF010044

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9EST4

PhosphoSite

PhosphoSite-Q9EST4

TrEMBL

UniProt Splice Variant

Entrez Gene

107047

UniGene

RefSeq

NP_598899

MGI ID

MGI Symbol

Psmg2

OMIM

CCDS

CCDS29324

HPRD

IMGT

EMBL

AB031387 AK006069 AK077569 AK135578 AK167840 BC016606

GenPept

AAH16606 BAB11962 BAC25130 BAC36869 BAE22586 BAE39861