InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: 2410016O06Rik

Summary

InnateDB Protein

IDBP-155896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

2410016O06Rik

Protein Name

RIKEN cDNA 2410016O06 gene

Synonyms

MAPJD; NO66;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057984

InnateDB Gene

IDBG-155894 (2410016O06Rik)

Protein Structure

UniProt Annotation

Function

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation (By similarity). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). {ECO:0000250, ECO:0000269PubMed:19927124}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000269PubMed:14742713, ECO:0000269PubMed:19927124}.

Disease Associations

Tissue Specificity

Present in developing bones (at protein level). Widely but not ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032453	histone demethylase activity (H3-K4 specific)
GO:0051864	histone demethylase activity (H3-K36 specific)

Biological Process

GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0034720	histone H3-K4 demethylation
GO:0042254	ribosome biogenesis
GO:0045668	negative regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process
GO:0070544	histone H3-K36 demethylation