InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Umps

Summary

InnateDB Protein

IDBP-155911.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Umps

Protein Name

uridine monophosphate synthetase

Synonyms

1700095D23Rik; AA408257; AL033308; BB164745;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023510

InnateDB Gene

IDBG-155909 (Umps)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004588	orotate phosphoribosyltransferase activity
GO:0004590	orotidine-5'-phosphate decarboxylase activity

Biological Process

GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222	UMP biosynthetic process
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0008152	metabolic process
GO:0009116	nucleoside metabolic process
GO:0035690	cellular response to drug
GO:0044205	'de novo' UMP biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1298388

InterPro

IPR000836 Phosphoribosyltransferase domain
IPR001754 Orotidine 5\'-phosphate decarboxylase domain
IPR004467 Orotate phosphoribosyl transferase domain
IPR011060 Ribulose-phosphate binding barrel
IPR014732 Orotidine 5\'-phosphate decarboxylase
IPR029057 Phosphoribosyltransferase-like

PFAM

PF00156
PF00215

PRINTS

PIRSF

SMART

SM00934

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13439