InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nodal

Summary

InnateDB Protein

IDBP-155935.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nodal

Protein Name

nodal

Synonyms

Tg.413d;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039653

InnateDB Gene

IDBG-155933 (Nodal)

Protein Structure

UniProt Annotation

Function

Essential for mesoderm formation and axial patterning during embryonic development. {ECO:0000269PubMed:8429908, ECO:0000269PubMed:8582278}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0048018	receptor agonist activity
GO:0070698	type I activin receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001702	gastrulation with mouth forming second
GO:0001707	mesoderm formation
GO:0001829	trophectodermal cell differentiation
GO:0001831	trophectodermal cellular morphogenesis
GO:0001842	neural fold formation
GO:0001889	liver development
GO:0001890	placenta development
GO:0001892	embryonic placenta development
GO:0001893	maternal placenta development
GO:0001944	vasculature development
GO:0001947	heart looping
GO:0002085	inhibition of neuroepithelial cell differentiation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007368	determination of left/right symmetry
GO:0007369	gastrulation
GO:0007399	nervous system development
GO:0007420	brain development
GO:0007492	endoderm development
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0009880	embryonic pattern specification
GO:0009948	anterior/posterior axis specification
GO:0009952	anterior/posterior pattern specification
GO:0009966	regulation of signal transduction
GO:0010085	polarity specification of proximal/distal axis
GO:0010470	regulation of gastrulation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016477	cell migration
GO:0019827	stem cell maintenance
GO:0022409	positive regulation of cell-cell adhesion
GO:0030324	lung development
GO:0032927	positive regulation of activin receptor signaling pathway
GO:0033505	floor plate morphogenesis
GO:0035050	embryonic heart tube development
GO:0035987	endodermal cell differentiation
GO:0038092	nodal signaling pathway
GO:0040007	growth
GO:0042074	cell migration involved in gastrulation
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045165	cell fate commitment
GO:0045596	negative regulation of cell differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048327	axial mesodermal cell fate specification
GO:0048382	mesendoderm development
GO:0048546	digestive tract morphogenesis
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048729	tissue morphogenesis
GO:0048859	formation of anatomical boundary
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0055123	digestive system development
GO:0060136	embryonic process involved in female pregnancy
GO:0060137	maternal process involved in parturition
GO:0060391	positive regulation of SMAD protein import into nucleus
GO:0060395	SMAD protein signal transduction
GO:0060460	left lung morphogenesis
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0060802	epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090009	primitive streak formation
GO:0090010	transforming growth factor beta receptor signaling pathway involved in primitive streak formation
GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:1901164	negative regulation of trophoblast cell migration
GO:1901383	negative regulation of chorionic trophoblast cell proliferation