InnateDB Protein
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IDBP-15594.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMEM66
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Protein Name
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transmembrane protein 66
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000256255
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InnateDB Gene
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IDBG-15592 (TMEM66)
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Protein Structure
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Function |
Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. {ECO:0000269PubMed:22464749}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:22464749}; Single-pass type I membrane protein {ECO:0000269PubMed:22464749}. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1- dependent manner following cytosolic Ca(2+) elevation.Isoform 2: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
Highly expressed in macrophages. {ECO:0000269Ref.2}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0070588
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calcium ion transmembrane transport
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GO:2001256
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regulation of store-operated calcium entry
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Cellular Component |
GO:0030176
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integral component of endoplasmic reticulum membrane
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PDB ID |
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InterPro |
IPR009567
Protein of unknown function DUF1183, TMEM66
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PFAM |
PF06682
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96BY9
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PhosphoSite |
PhosphoSite-Q96BY9
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TrEMBL |
E5RHW0
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UniProt Splice Variant |
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Entrez Gene |
51669
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UniGene |
Hs.521487
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RefSeq |
NP_057211
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HUGO |
HGNC:28789
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OMIM |
614768
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CCDS |
CCDS6074
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HPRD |
08651
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IMGT |
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EMBL |
AB028926
AC044849
AF078855
AF100748
AF490252
AK075340
AK222632
AK295360
AK315956
AY359104
BC015012
CH471080
JQ348891
JQ348892
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GenPept |
AAD43012
AAD44487
AAH15012
AAO85460
AAQ89462
AEZ06361
AEZ06362
BAB82465
BAD96352
BAG52116
BAH12043
BAH14327
EAW63471
EAW63472
EAW63474
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