InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Seh1l

Summary

InnateDB Protein

IDBP-156023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Seh1l

Protein Name

SEH1-like (S. cerevisiae

Synonyms

2610007A16Rik; AW540070; SEC13L; Seh1; SEH1A; SEH1B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025421

InnateDB Gene

IDBG-250534 (Seh1l)

Protein Structure

UniProt Annotation

Function

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (By similarity). As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Chromosome, centromere, kinetochore {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0002534	cytokine production involved in inflammatory response
GO:0006999	nuclear pore organization
GO:0007080	mitotic metaphase plate congression
GO:0015031	protein transport
GO:0050830	defense response to Gram-positive bacterium
GO:0051028	mRNA transport
GO:0051315	attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation