Version 5.4
Mus musculus Protein: Acot3
Summary
InnateDB Protein IDBP-156092.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acot3
Protein Name acyl-CoA thioesterase 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000021653
InnateDB Gene IDBG-156088 (Acot3)
Protein Structure
UniProt Annotation
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Mainly active on long-chain acyl-CoAs. May have a function in termination of beta-oxidation of fatty acids.
Subcellular Localization Peroxisome.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in the kidney, expressed at low level in the liver. Isoform 2 is expressed in the kidney, but not in the liver. Isoform 1 is expressed in more liver-specific. {ECO:0000269PubMed:10567408}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016290 palmitoyl-CoA hydrolase activity
GO:0016790 thiolester hydrolase activity
GO:0047617 acyl-CoA hydrolase activity
Biological Process
GO:0000038 very long-chain fatty acid metabolic process
GO:0001676 long-chain fatty acid metabolic process
GO:0006637 acyl-CoA metabolic process
GO:0032788 saturated monocarboxylic acid metabolic process
GO:0032789 unsaturated monocarboxylic acid metabolic process
Cellular Component
GO:0005777 peroxisome
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:2159619
InterPro IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
IPR016662 Acyl-CoA thioesterase, long chain
IPR029058 Alpha/Beta hydrolase fold
PFAM PF04775
PF08840
PRINTS
PIRSF PIRSF016521
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QYR7
PhosphoSite PhosphoSite-Q9QYR7
TrEMBL Q53YL1
UniProt Splice Variant
Entrez Gene 171281
UniGene Mm.202331
RefSeq NP_599007
MGI ID
MGI Symbol Acot3
OMIM
CCDS CCDS26036
HPRD
IMGT
EMBL AF180802 AF180803 AF180804 AY563097 AY563098 BC138741 BC138743
GenPept AAF13873 AAI38742 AAI38744 AAS75455 AAS75456

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca