InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ggnbp1

Summary

InnateDB Protein

IDBP-156126.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ggnbp1

Protein Name

gametogenetin binding protein 1

Synonyms

0610031G08Rik; mdf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051800

InnateDB Gene

IDBG-156124 (Ggnbp1)

Protein Structure

UniProt Annotation

Function

Induces mitochondrial fragmentation, possibly by promoting DNM1L-dependent fission and may play a role in mitochondrial morphogenesis during spermatogenesis. {ECO:0000269PubMed:19208545}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus. Mitochondrion intermembrane space.

Disease Associations

Tissue Specificity

Testis-specific. In the testis, expressed only in germ cells and not in somatic cells. Expression starts in late primary spermatocytes in stage X-XII tubules and gradually increases towards step 1-3 spermatids in stage I-III tubules. Expression then declines continuously and disappears after step 7 spermatids in stage VII tubules (at protein level). {ECO:0000269PubMed:19208545}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000266	mitochondrial fission
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation

Cellular Component

GO:0005758	mitochondrial intermembrane space
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:3055306

InterPro

IPR029071 Ubiquitin-related domain

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6K1E7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

70772

UniGene

Mm.482919

RefSeq

NP_081820

MGI ID

MGI Symbol

Ggnbp1

OMIM

CCDS

CCDS28559

HPRD

IMGT

EMBL

AB250379 AK077129 AY141192 BC049764 CH466606

GenPept

AAH49764 AAN10253 BAC36632 BAH22703 EDL22529