InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hand2

Summary

InnateDB Protein

IDBP-156151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hand2

Protein Name

heart and neural crest derivatives expressed transcript 2

Synonyms

AI225906; AI661148; bHLHa26; dHAND; Ehand2; Hed; Th2; Thing2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044983

InnateDB Gene

IDBG-156149 (Hand2)

Protein Structure

UniProt Annotation

Function

Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. {ECO:0000269PubMed:10769237, ECO:0000269PubMed:10804186, ECO:0000269PubMed:9171826, ECO:0000269PubMed:9671575}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Heart and aorta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003680	AT DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0033613	activating transcription factor binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0001947	heart looping
GO:0001967	suckling behavior
GO:0003007	heart morphogenesis
GO:0003219	cardiac right ventricle formation
GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003266	regulation of secondary heart field cardioblast proliferation
GO:0003278	apoptotic process involved in heart morphogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007507	heart development
GO:0007512	adult heart development
GO:0010463	mesenchymal cell proliferation
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0014032	neural crest cell development
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042733	embryonic digit morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043586	tongue development
GO:0045668	negative regulation of osteoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048485	sympathetic nervous system development
GO:0048538	thymus development
GO:0048935	peripheral nervous system neuron development
GO:0060021	palate development
GO:0060485	mesenchyme development
GO:0060536	cartilage morphogenesis
GO:0060982	coronary artery morphogenesis
GO:0061032	visceral serous pericardium development
GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061325	cell proliferation involved in outflow tract morphogenesis
GO:0061371	determination of heart left/right asymmetry
GO:2000679	positive regulation of transcription regulatory region DNA binding
GO:2000763	positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process
GO:2000764	positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis