Version 5.4
Mus musculus Protein: Acot5
Summary
InnateDB Protein IDBP-156157.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acot5
Protein Name acyl-CoA thioesterase 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000042019
InnateDB Gene IDBG-156155 (Acot5)
Protein Structure
UniProt Annotation
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Seems to be involved in intraperoxisomal regulation of acyl-CoA levels, but not CoASH levels. Mainly active on medium-chain acyl- CoAs. May have a function in termination of beta-oxidation of fatty acids. {ECO:0000269PubMed:15007068}.
Subcellular Localization Peroxisome.
Disease Associations
Tissue Specificity Highly expressed in spleen, brain, testis and proximal and distal intestine; expressed at low level in the liver. {ECO:0000269PubMed:15007068}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016290 palmitoyl-CoA hydrolase activity
GO:0016790 thiolester hydrolase activity
GO:0047617 acyl-CoA hydrolase activity
Biological Process
GO:0000038 very long-chain fatty acid metabolic process
GO:0001676 long-chain fatty acid metabolic process
GO:0006637 acyl-CoA metabolic process
GO:0032788 saturated monocarboxylic acid metabolic process
GO:0032789 unsaturated monocarboxylic acid metabolic process
Cellular Component
GO:0005777 peroxisome
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:2384969
InterPro IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
IPR016662 Acyl-CoA thioesterase, long chain
IPR029058 Alpha/Beta hydrolase fold
PFAM PF04775
PF08840
PRINTS
PIRSF PIRSF016521
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6Q2Z6
PhosphoSite PhosphoSite-Q6Q2Z6
TrEMBL
UniProt Splice Variant
Entrez Gene 217698
UniGene Mm.484019
RefSeq NP_663419
MGI ID
MGI Symbol Acot5
OMIM
CCDS CCDS26037
HPRD
IMGT
EMBL AC125071 AY563099
GenPept AAS75457

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca