Version 5.4
Mus musculus Protein: Pdzd3
Summary
InnateDB Protein IDBP-156171.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdzd3
Protein Name PDZ domain containing 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000034618
InnateDB Gene IDBG-156169 (Pdzd3)
Protein Structure
UniProt Annotation
Function Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=In kidney, predominantly localized to the subapical compartment of proximal tubular cells. In intestinal epithelial cells, localizes to the ileal brush border and in a juxtanuclear compartment. {ECO:0000269PubMed:11099500, ECO:0000269PubMed:19088451}.
Disease Associations
Tissue Specificity Expressed in kidney and small intestine. Not detected in heart, brain, spleen, lung, liver, skeletal muscle or testis. {ECO:0000269PubMed:11099500}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0030251 guanylate cyclase inhibitor activity
Biological Process
GO:0031283 negative regulation of guanylate cyclase activity
Cellular Component
GO:0005903 brush border
GO:0010008 endosome membrane
GO:0035003 subapical complex
GO:0045177 apical part of cell
Protein Structure and Domains
PDB ID MGI:2429554
InterPro IPR001478 PDZ domain
PFAM PF00595
PF13180
PRINTS
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99MJ6
PhosphoSite PhosphoSite-Q99MJ6
TrEMBL
UniProt Splice Variant
Entrez Gene 170761
UniGene Mm.29872
RefSeq NP_573489
MGI ID
MGI Symbol Pdzd3
OMIM
CCDS CCDS23099
HPRD
IMGT
EMBL AF334612 AK052748
GenPept AAK20865 BAC35130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca