Version 5.4
Mus musculus Protein: Slc39a4
Summary
InnateDB Protein IDBP-156182.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc39a4
Protein Name solute carrier family 39 (zinc transporter), member 4
Synonyms 1600025H15Rik; AU041686; AWMS2; ZIP4;
Species Mus musculus
Ensembl Protein ENSMUSP00000073134
InnateDB Gene IDBG-156180 (Slc39a4)
Protein Structure
UniProt Annotation
Function Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability. {ECO:0000269PubMed:12801924}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:14612438}; Multi-pass membrane protein {ECO:0000269PubMed:14612438}. Recycling endosome membrane {ECO:0000269PubMed:14612438}; Multi- pass membrane protein {ECO:0000269PubMed:14612438}. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.
Disease Associations
Tissue Specificity Highly expressed in the small intestine and embryonic visceral yolk sac. Weakly expressed in the stomach and liver. Found to the apical surface of enterocytes and visceral endoderm cells during zinc deficiency. {ECO:0000269PubMed:12801924}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005385 zinc ion transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006829 zinc ion transport
GO:0006882 cellular zinc ion homeostasis
GO:0030001 metal ion transport
GO:0034224 cellular response to zinc ion starvation
GO:0055085 transmembrane transport
GO:0071577 zinc ion transmembrane transport
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016324 apical plasma membrane
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1919277
InterPro IPR003689 Zinc/iron permease
PFAM PF02535
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q78IQ7
PhosphoSite PhosphoSite-Q78IQ7
TrEMBL Q3U263
UniProt Splice Variant
Entrez Gene 72027
UniGene Mm.276829
RefSeq NP_082340
MGI ID
MGI Symbol Slc39a4
OMIM
CCDS CCDS27578
HPRD
IMGT
EMBL AB052762 AK146977 AK147107 AK154089 AK155467 BC023498
GenPept AAH23498 BAC53795 BAE27581 BAE27679 BAE32367 BAE33279

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca