InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Efemp1

Summary

InnateDB Protein

IDBP-156388.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Efemp1

Protein Name

epidermal growth factor-containing fibulin-like extracellular matrix protein 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020759

InnateDB Gene

IDBG-156386 (Efemp1)

Protein Structure

UniProt Annotation

Function

Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Localizes to the lamina propria underneath the olfactory epithelium. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005006	epidermal growth factor-activated receptor activity
GO:0005154	epidermal growth factor receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032331	negative regulation of chondrocyte differentiation