Version 5.4
Homo sapiens Protein: LEPROTL1
Summary
InnateDB Protein IDBP-15639.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEPROTL1
Protein Name leptin receptor overlapping transcript-like 1
Synonyms HSPC112; my047; Vps55;
Species Homo sapiens
Ensembl Protein ENSP00000314625
InnateDB Gene IDBG-15637 (LEPROTL1)
Protein Structure
UniProt Annotation
Function Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269PubMed:19907080}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007262 Vacuolar protein sorting 55
PFAM PF04133
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95214
PhosphoSite PhosphoSite-
TrEMBL Q6FHL7
UniProt Splice Variant
Entrez Gene 23484
UniGene Hs.643148
RefSeq NP_056159
HUGO HGNC:6555
OMIM 607338
CCDS CCDS6075
HPRD 09551
IMGT
EMBL AC026979 AC044849 AF063605 AK075363 AL546441 AY277595 AY358674 BC000642 CH471080 CR541735 CR541760
GenPept AAC98697 AAH00642 AAQ18034 AAQ89037 BAG52122 CAG46535 CAG46560 EAW63469 EAW63470

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca