InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hinfp

Summary

InnateDB Protein

IDBP-156399.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hinfp

Protein Name

histone H4 transcription factor

Synonyms

AA589481; HiNF-P; Mizf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034629

InnateDB Gene

IDBG-156397 (Hinfp)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. {ECO:0000269PubMed:17826007}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Associated with discrete nuclear foci. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042393	histone binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0001701	in utero embryonic development
GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0045184	establishment of protein localization
GO:0045445	myoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated