InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgs12

Summary

InnateDB Protein

IDBP-156423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs12

Protein Name

regulator of G-protein signaling 12

Synonyms

1200016K18Rik; 4632412M04Rik; AI481290; E130309H11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030984

InnateDB Gene

IDBG-156421 (Rgs12)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain. {ECO:0000269PubMed:15525537}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0030695	GTPase regulator activity

Biological Process

GO:0007165	signal transduction
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1918979

InterPro

IPR000342 Regulator of G protein signalling domain
IPR001478 PDZ domain
IPR003109 GoLoco motif
IPR003116 Raf-like Ras-binding
IPR006020 PTB/PI domain
IPR016137 Regulator of G protein signalling superfamily
IPR029071 Ubiquitin-related domain

PFAM