InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dclk2

Summary

InnateDB Protein

IDBP-156431.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dclk2

Protein Name

doublecortin-like kinase 2

Synonyms

6330415M09Rik; AU044875; CL2; Click-II; CLICK2; Dcamkl2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029719

InnateDB Gene

IDBG-156429 (Dclk2)

Protein Structure

UniProt Annotation

Function

Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm. {ECO:0000269PubMed:16684769}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:16628014, ECO:0000269PubMed:16684769}. Note=Colocalizes with microtubules.

Disease Associations

Tissue Specificity

Expressed in the central and peripheral nervous system including the brain, spinal cord, cranial and dorsal root ganglia and in the parasympathetic ganglia. Present in neurons, but not in glial cells, in most forebrain areas. Strong expression in the hippocampal CA1 pyramidal cell layer. Expressed in the photoreceptor sensory cilium complex and in eyes. Also detected in individual cells of the olfactory epithelium. {ECO:0000269PubMed:16684769, ECO:0000269PubMed:16869982, ECO:0000269PubMed:18075264, ECO:0000269PubMed:19342486}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1918012

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003533 Doublecortin domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF03607

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00537
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt