InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnmt

Summary

InnateDB Protein

IDBP-156448.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnmt

Protein Name

RNA (guanine-7-) methyltransferase

Synonyms

2610002P10Rik; AI848273; mKIAA0398; Rg7mt1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009679

InnateDB Gene

IDBG-156446 (Rnmt)

Protein Structure

UniProt Annotation

Function

mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004482	mRNA (guanine-N7-)-methyltransferase activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity

Biological Process

GO:0006370	7-methylguanosine mRNA capping
GO:0008152	metabolic process
GO:0036265	RNA (guanine-N7)-methylation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005845	mRNA cap binding complex
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:1915147

InterPro

IPR004971 mRNA (guanine-N(7))-methyltransferase domain
IPR013216 Methyltransferase type 11
IPR016899 mRNA (guanine-N(7))-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF03291
PF08241

PRINTS

PIRSF

PIRSF028762

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D0L8