InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Polr1a

Summary

InnateDB Protein

IDBP-156511.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Polr1a

Protein Name

polymerase (RNA) I polypeptide A

Synonyms

194kDa; 3010014K16Rik; mRPA1; RPA194; Rpo1-4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000060858

InnateDB Gene

IDBG-156509 (Polr1a)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001054	RNA polymerase I activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005736	DNA-directed RNA polymerase I complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1096397

InterPro

IPR000722 RNA polymerase, alpha subunit
IPR006592 RNA polymerase, N-terminal
IPR007066 RNA polymerase Rpb1, domain 3
IPR007080 RNA polymerase Rpb1, domain 1
IPR007081 RNA polymerase Rpb1, domain 5
IPR007083 RNA polymerase Rpb1, domain 4

PFAM

PF00623
PF04983
PF04997
PF04998
PF05000

PRINTS

PIRSF

SMART

SM00663

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35134